It is critical for staff and visitors to understand the required protocol and procedures prior to entering an isolation room. Detailed information needs to be posted at the door, indicating entry and exit procedures as well as the necessary PPE for each isolation type. Herter Design Group was tasked by NewYork-Presbyterian with designing changeable insert signs for 11 unique types/combinations of isolation. Because the NYP system encompasses most of New York City’s five boroughs, each isolation insert layout was required to be designed with multiple languages: English, English/Spanish, and English/Traditional Chinese.